Halneuron®
非阿片类止痛药​

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Wong D, Korz W. Tetrodotoxin treatment of mechanical allodynia in rats with oxaliplatin and vincristine-induced neuropathy.

American Pain Society 34th annual scientific meeting
May 13-16, 2015. Palm Springs, CA, USA

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Clifford JL, Salas MM, McIntyre M, Wong D, Korz W. Tetrodotoxin attenuates thermal hyperalgesia in a rat full thickness thermal injury pain model.

American Pain Society 34th annual scientific meeting
May 13-16, 2015. Palm Springs, CA, USA

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Hagen NA, Cantin L, Constant J, Haller T, Blaise G,  Ong–Lam M, du Souich P, Korz W, Lapointe B. Tetrodotoxin for moderate to severe cancer-related pain: a multicentre, randomized, double-blind, placebo-controlled, parallel-design trial.

Canadian Pain Society 36th annual scientific meeting
May 20-23, 2015. Charlottetown, PEI. Canada

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Goldlust S, Kavoosi M, Korz W, Deck K. Tetrodotoxin for chemotherapy induced neuropathic pain.

American Academy of Pain Management 26th annual clinical meeting
September 17-20, 2015. Washington, DC, USA.

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Goldlust S, Kavoosi M, Korz W, Deck K. Tetrodotoxin (TTX) for Chemotherapy Induced Neuropathic Pain (CINP): A Randomized, Double-Blind, Dose-Finding, Placebo Controlled, Multicenter Study.

American Academy of Neurology 68th annual meeting
April 15-21, 2016. Vancouver, BC, Canada

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Ruckle J, Wong D, Kavoosi M, Korz W, Wei H, Zhao F, Spanswick D, Livezey V. The Peripheral Action of Tetrodotoxin: A Translational Research Study.

IASP 16th World Congress on Pain
Sep 26-30, 2016. Yokohama, Japan.

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Wong D, Korz W, Wei H, Zhao F, Spanswick D. An Electrophysiological Examination on the Mechanism of Action of Tetrodotoxin for the Treatment of Chemotherapy-induced Neuropathic Pain in a Rat Model of Oxaliplatin-Induced Peripheral Neuropathy.

International Association for the Study of Pain (IASP) World Congress on Pain
September 19-23, 2022. Toronto, Ontario, Canada.

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Wong D, Korz W, Awaga Y, Yano M, Fujii R, Natsume T, Hama A, Takamatsu H. Reduced Pain and Regional Brain Activation following Tetrodotoxin (TTX) Treatment in a Cynomolgus Model of Post-operative Pain.

13th Congress of the European Pain Federation (EFIC®)
September 20-22, 2023. Budapest, Hungary.

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科学出版物

有 WEX 作者的出版物列表

Marcil J, Walczak JS, Guindon J, Ngoc AH, Lu S, Beaulieu P. Antinociceptive effects of tetrodotoxin (TTX) in rodents.

Br J Anaesth. 2006 Jun;96(6):761-8.

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Hagen NA, Fisher KM, Lapointe B, du Souich P, Chary S, Moulin D, Sellers E, Ngoc AH; Canadian Tetrodotoxin Study Group. An open-label, multi-dose efficacy and safety study of intramuscular tetrodotoxin in patients with severe cancer-related pain.

J Pain Symptom Manage. 2007 Aug;34(2):171-82.

Guzmán A, Fernández de Henestrosa AR, Marín AP, Ho A, Borroto JI, Carasa I, Pritchard L. Evaluation of the genotoxic potential of the natural neurotoxin Tetrodotoxin (TTX) in a battery of in vitro and in vivo genotoxicity assays.

Mutat Res. 2007 Dec 1;634(1-2):14-24.

Hagen NA, du Souich P, Lapointe B, Ong-Lam M, Dubuc B, Walde D, Love R, Ngoc AH; Canadian Tetrodotoxin Study Group. Tetrodotoxin for moderate to severe cancer pain: a randomized, double blind, parallel design multicenter study.

J Pain Symptom Manage. 2008 Apr;35(4):420-9.

Hagen NA, Lapointe B, Ong-Lam M, Dubuc B, Walde D, Gagnon B, Love R, Goel R, Hawley P, Ngoc AH, du Souich P. A multicentre open-label safety and efficacy study of tetrodotoxin for cancer pain.

Curr Oncol. 2011 Jun;18(3):e109-16.

Berde CB, Athiraman U, Yahalom B, Zurakowski D, Corfas G, Bognet C. Tetrodotoxin-bupivacaine-epinephrine combinations for prolonged local anesthesia.

Mar Drugs. 2011 Dec;9(12):2717-28.

Hagen NA, Cantin L, Constant J, Haller T, Blaise G, Ong-Lam M, du Souich P, Korz W, Lapointe B. Tetrodotoxin for Moderate to Severe Cancer-Related Pain: A Multicentre, Randomized, Double-Blind, Placebo-Controlled, Parallel-Design Trial.

Pain Res Manag. 2017;2017:7212713.

Kavoosi M, O’Reilly TE, Kavoosi M, Chai P, Engel C, Korz W, Gallen CC, Lester RM. Safety, Tolerability, Pharmacokinetics, and Concentration-QTc Analysis of Tetrodotoxin: A Randomized, Dose Escalation Study in Healthy Adults.

Toxins (Basel). 2020 Aug 9;12(8):511.

Goldlust SA, Kavoosi M, Nezzer J, Kavoosi M, Korz W, Deck K. Tetrodotoxin for Chemotherapy-Induced Neuropathic Pain: A Randomized, Double-Blind, Placebo-Controlled, Parallel-Dose Finding Trial.

Toxins (Basel). 2021 Mar 25;13(4):235.

没有WEX 作者的出版物列表

González-Cano R, Ruiz-Cantero MC, Santos-Caballero M, Gómez-Navas C, Tejada MÁ, Nieto FR. Tetrodotoxin, a Potential Drug for Neuropathic and Cancer Pain Relief?

Toxins. 2021 Jul 12;13(7):483.

Berde CB, Athiraman U, Yahalom B, Zurakowski D, Corfas G, Bognet C. Tetrodotoxin-bupivacaine-epinephrine combinations for prolonged local anesthesia.

Mar Drugs. 2011 Dec;9(12):2717-28.